以色列理工學院Ashraf Brik教授學術講座--Chemical Biology with Ubiquitin Signaling (泛素信號的化學生物學研究)

聯系人:孫浩聯系方式:19852809350發布時間:2021-09-09

時間:2021年9月23日 16:00
Zoom直播鏈接:https://us06web.zoom.us/j/2481394479?pwd=TTZTaHFDQW1sa3pJa2l3NUxqOWhhQT09
Zoom直播會議號:2481394479,密碼:032853
報告人: Ashraf Brik教授
邀請人:孫浩(理學院)

報告人簡介:
Ashraf Brik is a professor at Technion-Israel Institute of Technology. He moved from Ben-Gurion University to Technion in 2015, where he holds the Jordan and Irene Tark Academic Chair. In 2017, he got the Henry Taub Prize for Academic Excellence. In 2018, he became the member of Israel Young Academy. In 2019, he was supported by the ERC advanced grant. In 2020, he got the Israel Chemical Society Prize of Excellence. His research involves the development of novel chemistries and approaches for the chemical synthesis and semi-synthesis of post-translationally modified proteins (e.g. ubiquitinated, glycosylated and phosphorylated proteins) for biochemical, biophysical and biological studies. His group is also interested in the design and synthesis of modulators based on small molecules, peptides and peptidomimetics for enzymes which are involved in various diseases.
Ashraf Brik是以色列理工學院的教授,他于2015年從本古里安大學轉到以色列理工學院,擔任約旦和艾琳塔克學術主席。2017 年,他獲得了亨利·陶布學術卓越獎。2018年他成為以色列青年學院成員。2019年他獲得歐洲ERC基金高級資助。2020年,他獲得以色列化學學會卓越獎。他的研究涉及用于生物化學、生物物理和生物學研究的翻譯后修飾蛋白質(例如泛素化、糖基化和磷酸化蛋白質)的化學合成和半合成的新型化學和方法的開發。另外,他團隊的研究興趣還涉及基于小分子、肽和肽模擬物的調節劑的設計和合成,這些調節劑與各種疾病相關。

講座內容簡介:

Ubiquitination is an important post-translation modification affecting a variety of biological processes such as protein degradation, trafficking, transcription and the DNA damage response. Not surprisingly, ubiquitination plays a key role in various diseases, such as neurological disorders, infectious diseases and cancer. The recent breakthrough in chemical and semisynthetic approaches reported by Brik’s group makes it possible now to assemble ubiquitin chains and ubiquitinated peptides and proteins in high purity and large quantity. As a result, great opportunities have become now available for chemical biologists and biologists to study the ubiquitin signal at the molecular level to reveal unknown aspects of this amazing and diverse signal.
泛素化是一種重要的翻譯后修飾,影響多種生物過程,如蛋白質降解、運輸、轉錄和 DNA 損傷反應。毫不奇怪,泛素化在各種疾病中起著關鍵作用,例如神經系統疾病、傳染病和癌癥。Brik 小組發展的化學合成和半合成方法的最新突破使現在可以高純度和大量組裝泛素鏈和泛素化肽和蛋白質。因此,化學生物學家和生物學家現在有很大的機會在分子水平上研究泛素信號,以揭示這種驚人而多樣信號的未知領域。

 

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